Home » PCOS » PCOS, Your Hypothalamus and Progesterone

PCOS, Your Hypothalamus and Progesterone

by | Last updated: Oct 11, 2023 | Hypothalamus, PCOS | 0 comments

Let’s talk about PCOS, your hypothalamus, and progesterone. 

Polycystic Ovary Syndrome affects ten percent of women.

PCOS is one of the most common metabolic conditions for women of reproductive years. And your hypothalamus is at the root of the metabolic issues related to polycystic ovary syndrome. In PCOS, the hypothalamic-pituitary-ovarian axis is dysfunctional creating a metabolic as well as reproductive hormone imbalances.

In polycystic ovary syndrome, androgens are prominent including testosterone and DHEA. Yet progesterone is low creating estrogen dominance – meaning estrogen is out of balance with progesterone. Insulin resistance occurs which is the cornerstone of the metabolic issues.

In polycystic ovary syndrome, the theca cells of the ovary which produce testosterone the precursor hormone to estrogen, become insulin resistant. More and more testosterone is produced converting into more and more estradiol but ovulation is not occurring – so not enough progesterone is produced to counterbalance the high estrogen.

Polycystic ovary syndrome can contribute to infertility because of lack of ovulation. Even if a woman with PCOS does get pregnant, she oftentimes will miscarry because she does not produce not enough progesterone to maintain an early pregnancy. 

So what is the most effective treatment for polycystic ovary syndrome?

In my patients with PCOD, I have found that supporting the hypothalamus with Genesis Gold® has corrected many of the metabolic issues including insulin resistance, anovulation, and hormone imbalances. Some of my patients will require supplemental progesterone, especially if they want to get pregnant and avoid miscarriage.

Fortunately, we now have Gen-Pro available. 


Gen-Pro is the prescription-grade transdermal progesterone in a liposomal base that my patients with polycystic ovary syndrome have used successfully for over 30 years.

This highly absorbable cream is a true transdermal and has been very effective in keeping women who threaten miscarriage pregnant.  All of my polycystic ovary syndrome patients start by taking Genesis Gold® at their body weight, which is four grams per 50 pounds of body weight.

Unusually within three to six months of taking Genesis Gold®, their menstrual cycles regulate and they start ovulating. If they’re still having issues, we add Gen-Pro transdermal progesterone cream to be used at about the time of ovulation which is often marked by spinbarkheidt – an egg white-like vaginal mucus that indicates high estrogen levels in the follicular phase.  

Gen-Pro transdermal cream is dosed at 100 to 200 milligrams twice daily and applied to the inner thigh for 10 to 14 days. If they get a period, great. If there’s any suspicion of pregnancy, they will do a urine pregnancy test and if positive continue Gen-Pro.

Progesterone levels can be lower usually about 50 to 100 milligrams daily is more than enough to maintain pregnancy. But to prevent miscarriage, we’ve got to continue to progesterone for the first 14 weeks of pregnancy.

If you have any questions, I explain polycystic ovary syndrome in depth as well as infertility and metabolic disorders in young reproductive women in my new book, The Hypothalamus Handbook.

You can join us in our Hormone Reboot Training where you’ll get discounts on both Genesis Gold® and Gen-Pro.

Hormone Reboot Training

Central Regulation of PCOS: Abnormal Neuronal-Reproductive-Metabolic Circuits in PCOS Pathophysiology; Baoying Liao, Jie Qiao, Yanli Pang; Frontiers in Endocrinology (Lausanne); 2021; 12: 667422  

About the Author - Deborah Maragopoulos FNP

Known as the Hormone Queen®️, I’ve made it my mission to help everyone – no matter their age – balance their hormones, and live the energy and joy their DNA and true destiny desires. See more about me my story here…



Submit a Comment

Your email address will not be published. Required fields are marked *