Estrogen Therapy and Blood Clots: What You NEED To Know

Let’s talk about the estradiol side effect of blood clots. 

Of all the side effects that estradiol may have, inducing blood clots is the most serious.

Estradiol is Not Alone in Inducing Blood Clots

All steroid hormones taken orally for more than six months can interfere with your liver’s clotting cascade and increase your risk of blood clots. These steroid hormones include estradiol, progesterone, testosterone, DHEA and cortisol.

Estradiol is particularly aggressive at stimulating blood clot formation. So it’s very important – if you have a clotting disorder, that you reveal it to your healthcare provider before considering hormonal birth control or hormone replacement therapy.

How To Prevent Blood Clots

One way that you can help to prevent blood clots from estradiol is using estradiol transdermally, through the skin, or sublingually underneath the tongue. These delivery mechanisms bypass the liver which prevents estradiol from interfering with a clotting cascade.

If you have any questions about estradiol and blood clots, please join us in our Hormone Reboot Training.

Resources:

https://pubmed.ncbi.nlm.nih.gov/32450447