Where’s the best place to apply transdermal Hormone creams?

by Deborah Maragopoulos FNP | Oct 26, 2017 | Blog, Men's Health

Bio-identical hormones are best delivered transdermally — through the skin. Unlike oral hormones, transdermal hormones bypass the liver so there is no interference with the clotting cascade. Thus, hormone creams are safer.

I prefer liposomal bases for transdermal hormones.

Liposomal delivery mechanisms help fat-soluble hormones penetrate the skin and get deposited into the subcutaneous fat allowing more consistent blood levels. It's best to apply transdermal hormone creams to clean skin and wait at least fifteen minutes before getting the skin wet like sweating.

Alcohol-based hormone creams do not deliver large hormone molecules past the dermis. Liposomal based transdermal progesterone and estrogen cream are best applied to the inner thighs. Alcohol-based creams are better applied to thinner skin like inner forearms.

For men, testosterone is best absorbed from upper inner arms.

Men need to be careful not to touch women, children, or pets until the cream, gel or liquid testosterone is completely absorbed, which usually takes 30 minutes.

Frequently Asked Questions

What is the Sunshine Protection Act?

The Sunshine Protection Act (H.R. 139) is federal legislation that would make daylight saving time permanent nationwide, ending the twice-yearly clock change. The U.S. House passed it on July 14, 2026, and it now awaits action in the Senate.

What's the difference between permanent daylight saving time and permanent standard time?

Both would end clock changes, but in opposite directions. Permanent standard time keeps clocks aligned with the sun so light arrives earlier in the morning. Permanent daylight saving time shifts clocks later year-round, meaning darker mornings — especially in winter — and more evening light.

Why do some sleep experts favor permanent standard time?

Many circadian researchers and the American Academy of Sleep Medicine have expressed support for permanent standard time, citing its closer alignment with natural light and the body's internal clock. The concern with permanent daylight saving time is the loss of morning light, which can influence sleep timing.

How does morning light affect the body?

Morning light exposure can help signal the brain's internal clock, which may support healthy sleep-wake timing, alertness, and hormone rhythms. Reduced morning light may make it harder for the body's clock to stay in sync. Individual responses vary, so speak with your provider about your own sleep concerns.

What is the suprachiasmatic nucleus (SCN)?

The SCN is a small cluster of neurons in the hypothalamus that acts as the body's master clock. It responds to light and dark cues and helps coordinate daily rhythms in sleep, hormone release, and metabolism.

About the Author - Deborah Maragopoulos FNP

Known as the Hormone Queen®️, I’ve made it my mission to help everyone - no matter their age - balance their hormones, and live the energy and joy their DNA and true destiny desires. See more about me my story here...

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Last Updated: April 14, 2022