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Are Artificial Sweeteners Safe? | Insulin Resistance

by | Jul 28, 2021 | Autoimmunity | 0 comments

This topic has been up for debate for what seems like ages. But, the question still remains: Are artificial sweeteners safe?

The short answer is, that science doesn’t always agree.

Let’s dive in and talk about the possible effects of artificial sweeteners on your health.

Most scientists disagree about the relationship between artificial sweeteners, cancers, and other diseases. Other diseases such as chronic fatigue syndrome, Parkinson’s disease, Alzheimer’s disease, Multiple Sclerosis, Autism, and Systemic Lupus. All of these conditions are subjectively related to the use of artificial sweeteners. But, we don’t have enough data to prove that they are the main cause.

My biggest issue with artificial sweeteners is just that. They’re artificial. 

When you eat or drink something that isn’t made by nature, it means your body has to deal with it in a different way. 

For many years, I have thought that artificial sweeteners actually change the way the body deals with its glucose metabolism. Anytime you eat something sweet (whether it’s real sugar or artificial) the receptors on your tongue tell your hypothalamus that you’re going to get sugar. The hypothalamus then prepares to receive glucose. However, when you use an artificial sweetener but don’t actually consume the calories, your body lets go of stored sugar. This is to feed your hypothalamus

Do artificial sweeteners help with weight loss?

I have observed many people drink diet beverages. I suspect that artificial sweeteners don’t really help you with weight loss. They may in the beginning if you replace real calories with negative calories. But it really doesn’t help you in the long run. This is because artificial sweeteners increase the event of insulin resistance, which contributes to body fat storage and obesity. 

Studies have found that when you give someone a drink that is either artificially or naturally sweetened, the rise in insulin and glucose in their blood ends up the same. When you tease your hypothalamus with artificial sweeteners, it has to continue to trigger the release of stored sugar. Eventually, you will become insensitive to the high levels of insulin in your blood and have more and more trouble losing weight. 

Children who consume artificial sweeteners are more likely to have issues with obesity and lipid metabolism. As well as insulin sensitivity.

Are artificial sweeteners safe for children? Research has found that children who consume artificial sweeteners before a meal will still consume the same amount of calories. They make up for the lack of calories from the artificial sweetener.

In fact, when you use artificial sweeteners, you will decrease your sensitivity to the sweetness. This indicates insulin resistance.

Weight loss success aside, the question still is:

Are these types of sweeteners safe?

Let’s compare the different types:

  • Saccharin is the first artificial sweetener, discovered in 1879. You may know these as the “pink” packets. Saccharin is 300 times sweeter than sugar and sweetens various food products. It’s also in cosmetic products such as toothpaste, mouthwash, lip gloss, vitamins, and medications. The research found that saccharin can cause cancer and is toxic to your liver. 
  • Acesulfame-K was discovered in 1967. It was used to decrease the bitter aftertaste of aspartame and is 200 times sweeter than sugar. Acesulfame-K’s toxicity is dose-related and can result in genetic damage. 
  • Sucralose was discovered in 1976 and is 600 times sweeter than sugar. It was approved in 1992 to be used in 15 different food categories. You may recognize sucralose as the “yellow” packets. As for its toxicity, it seems to shrink the thymus. This is a problem because your thymus programs your immune system and protects you from disease and cancer.

First approved in 1981 as a tabletop sweetener:

  • Aspartame is the “blue” packet. In 1996, it was approved as a general-purpose sweetener for foods and drinks. It’s 200 times sweeter than sucrose and is the most controversial of all the artificial sweeteners. This is because of the carcinogenic potential when aspartame exposure occurs during gestation. So if you are a pregnant woman and use this artificial sweetener, it’s more likely that your child will develop cancer. The controversy continues due to the fact that the ADI (acceptable daily intake) of aspartame is toxic. Aspartame can cause brain damage because it has metabolized into phenylalanine This is true especially when exposed in utero. It has also been associated with headaches, particularly migraines.  
  • Neotame is the newest artificial sweetener and is a byproduct of aspartame. It is 7,000 to 13,000 times sweeter than sugar. It has been approved by the FDA as a general-purpose sweetener since 2002. So far, it has no known toxicity. 

Regular use of artificial sweeteners can be damaging to your cells and DNA. Artificial sweeteners can cause issues with insulin resistance. This leads to a lack of weight loss results.

A recent study tested sweet perception with diabetic and non-diabetic people. Various amounts of sugar were dissolved in water, and those who were more insulin-resistant (diabetic) could hardly taste any sugar. Only people with healthy insulin receptors and healthy glucose metabolism could tell the smallest amount of sugar in water. What does this mean? If their taste receptors are blind due to high doses of artificial sweeteners, they’re going to need more sugar to tell the taste of sweetness. 

I suggest you use less and less sweetener until you learn to drink things that aren’t sweet at all. Your taste for sweetness will become much more clear, and you will crave less sugar. 

Learn more about how to reverse insulin resistance in my Hormone Reboot Training

So to answer the main question, are these sweeteners safe? No, not exactly. 

I advise you to use them with caution or cut them out completely. If you are pregnant, avoid artificial sweeteners at all costs.


Research Reference: Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study, Dietary sugars, not lipids, drive hypothalamic inflammation.


*Statements not reviewed by the FDA.


About the Author - Deborah Maragopolous FNP

Known as the Hormone Queen®️, I’ve made it my mission to help everyone – no matter their age – balance their hormones, and live the energy and joy their DNA and true destiny desires. See more about me my story here…



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