Receptor Sites: How to Increase Hormone Sensitivity Naturally

by Deborah Maragopoulos FNP | Dec 7, 2018 | Hypothalamus | 2 comments

If you want to know how to increase your sensitivity to your own hormones, or to bioidentical hormones, Read on! Welcome back to my blog. Today, I am going to tell you how to increase your natural hormone sensitivity. Why? Because less is more.

So, let us talk about what hormone sensitivity means. Your hormones have to get into your cells. When they are just not in your cells, your lack of hormones cause all kinds of issues and causing all kinds of reactions on the outside of the cell. Your hormones have to lock in and get into the cells in order to tell the cells what to do.

Your hormones do that at a part of the cell wall called the receptor sites.

Open receptor sites and many receptor sites make you more hormonally sensitive. But sometimes your receptor sites will be closed down and not allow the hormones to get in. In order for the hormones to work, we have to get into the cells. If you have receptor sites that are more active, more sensitive, then your hormones are going to work better.

Hormone Healing Tip 1: Heal Your Cell Membranes

Number one, heal cell membranes. Your cell membranes are kind of like a butter sandwich. Glycoprotein, lipids in the middle, and more glycoprotein. The cell receptor sites are within the cell membrane. So if your cell membranes are unhealthy, your cell receptor sites do not function normally.

So how do you heal your cell membranes? The first thing you want to do is to make sure you get enough fat in your diet. And I am not just talking about vegetable fats. I am also talking about saturated fats. One-third of your fats need to come from saturated sources. Those are animal sources. Though coconut oil is also a saturated source.

In order to really build healthy membranes, two-thirds of your fat can come from unsaturated sources, which are always plant-based fats and oil. Nuts, seeds, olive oil, as well. Without enough fat, you do not develop healthy cell membranes. Healthy cell membranes are where you make receptor sites.

Hormone Healing Tip: Clear Hormone Blockers

Number two, your receptor sites actually have to be cleared of hormone blockers. Certain things will actually block your receptor site from allowing the hormone to get in. The most classic hormone blockers are chemicals that actually sit on top of that receptor site and take up the receptor site so that the hormone cannot get in.

Typically, these would be xenoestrogens, they will be things like the BPA in plastics, the xenoestrogens in DDT. Anything that is what is called an endocrine disrupter actually blocks the hormone receptor so your hormones cannot do their job properly. The other thing that is really crucial in the receptor site functioning, normally, is whether or not these receptor sites are built with healthy minerals or heavy metals.

If you have heavy metal toxicity, your receptor sites oftentimes hold the metal, like mercury, arsenic, lead, within the receptor site.

Now, while it looks like a receptor site, the metal is not the proper lock where the key will fit in properly. It does not work properly. So heavy metal toxicity will definitely interfere with your hormone sensitivity. Chelating, or removing, those heavy metals out naturally is really key to actually help to increase that hormone sensitivity.

There are lots of protocols out there, most of which you should follow with a certified healthcare provider who knows how to chelate heavy metals from your system. They must also make sure your heavy metals are actually checked properly. This is usually done through a provoked urine challenge, where we actually look at your urine to see if you are actually urinating out an excessive amount of heavy metals, after taking a provocation ingredient or medication.

Hormone Healing Tip 2: Enhance your Hormone Sensitivity

The third thing that you need to do is increase your hormone sensitivity. The way you do that, if you have too many hormones in a system, is that your receptor sites can actually close down. We see this in insulin resistance when there are too much insulin and sugar floating around. You know how this works in another way;

This is not hormones, but a little different, and this will help you understand. If you have ever been cooking in the kitchen and, let us say you are sauteing some onions and you have the lid over the pan,  then you have someone else walk in the kitchen and tell you that they smell something burning. However you did not notice it, that is because your olfactory receptors, the receptor sites for the smell of the burning onions, were saturated in the smell. You had too much of that exposure and so you did not notice it. Where it was new to the other person, their cell receptors were not saturated.

In the same way, if you have too many hormones on board, you can over-saturate these receptor sites so that you are not as sensitive to them.

I see this all the time, when women or men, are put on bioidentical hormone replacement therapy and they are never given a break. You need to take a break from your hormones. So, if you are given hormone replacement, especially including bioidentical, but both synthetic or bioidentical. For females, if you do not take a 72-hour break, and males as well, you could overexpose yourself. You need 72 hours away from those hormones, three days, to clear the receptor sites so that when you reintroduce the hormones when your receptor sites are fresh and new and they will accept the hormones again.

That is one of the reasons why, when you are started on hormone replacement therapy, oftentimes it feels great in the first few months but then ceases to feel so great anymore. You do not really notice anything anymore. It is because you have not cleared your receptor sites and you have become resistant to your own hormones. You are not sensitive to them anymore. So taking that break is very important in order to keep that sensitivity going.

Frequently Asked Questions:

Can your hypothalamus cause weight gain?

Yes. The hypothalamus is the master regulator of metabolism, controlling how your body stores and burns energy through its signaling to the thyroid, adrenals, and pancreas. When the hypothalamus becomes dysregulated by chronic stress, poor sleep, inflammation, or blood sugar instability, it defends a higher weight "set point" — causing the body to hold onto fat regardless of diet or exercise. This makes hypothalamic dysfunction an upstream root cause of stubborn weight gain.


What is a weight set point and why won't mine move?

A weight set point is the body weight your hypothalamus works to defend, calibrated over time by stress, sleep, hormones, and inflammation. When you diet, the hypothalamus perceives scarcity and responds by slowing metabolism, increasing hunger hormones, and suppressing satiety signals to return you to that set point. This is why most people regain lost weight within two to five years of conventional dieting — the set point itself was never recalibrated, only temporarily overridden.


Why do I gain weight under stress even when I'm not eating more?

Chronic stress raises cortisol, which disrupts blood sugar regulation, promotes abdominal fat storage, and signals the hypothalamus that the body is under threat. In survival mode, the hypothalamus defends fat stores and slows metabolism — so weight can increase even without any change in calorie intake. The stress chemistry, not the food, is driving the weight gain, which is why stress reduction is essential to any lasting metabolic reset.


Why do I regain weight after stopping GLP-1 medications?

GLP-1 medications work peripherally on appetite and gastric signaling, but they do not address the underlying hypothalamic dysregulation that sets your defended weight. Because the hypothalamic set point is never recalibrated, the body resumes defending its original weight once the medication stops — leading to significant regain. Long-term success requires restoring hypothalamic regulation so the set point itself lowers, rather than relying on appetite suppression alone.


How long does it take to reset your metabolism?

Genuine metabolic recalibration takes a minimum of 90 days, because the hypothalamus needs consistent signals of safety and sufficiency before it will lower its defended set point. This differs from a diet, which produces temporary suppression the body quickly corrects. A 90-day reset typically moves through three phases: stabilizing stress chemistry (days 1–30), rebuilding metabolic efficiency (days 31–60), and lowering the weight set point (days 61–90).


Why does my thyroid feel slow even though my labs are "normal"?

Under chronic stress, the body converts thyroid hormone into reverse T3, which blocks active thyroid receptors and slows metabolism at the cellular level — even when standard lab values appear normal. This means you can experience genuine symptoms of slow metabolism, such as fatigue, cold intolerance, and brain fog, while your thyroid panel looks unremarkable. Addressing the upstream hypothalamic and stress signaling often improves thyroid conversion and symptoms.


Is stubborn weight gain a willpower problem?

No. Stubborn weight gain is a signaling problem, not a willpower problem. The hypothalamus governs weight through survival mechanisms that operate below conscious control — defending its set point by slowing metabolism and increasing hunger when it perceives threat. No amount of discipline can override this system; lasting change comes from restoring hypothalamic regulation through reduced stress, balanced blood sugar, restorative sleep, and targeted nutritional support.

About the Author - Deborah Maragopoulos FNP

Known as the Hormone Queen®️, I’ve made it my mission to help everyone - no matter their age - balance their hormones, and live the energy and joy their DNA and true destiny desires. See more about me my story here...

     

Last Updated: April 7, 2022

2 Comments

  1. Lori

    hi,
    how often should you take the 72 hour break from hrt?

    Reply

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